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American stock index futures maintained a downward trend, with S&P 500 E-MINI futures down 0.3%, Nasdaq futures down 0.6% and Dow Jones futures down 0.1%.Spot gold fell by $5 in the short term and is now reported at $2,704 per ounce.Novo Nordisk: After the clinical trial results of kidney therapy were released, European regulators gave Ozempic a positive label evaluation.

Macron said that it opposed the free trade agreement reached between the EU and MERCOSUR. On December 12th, local time, French President Macron, who was visiting Poland, said that he disagreed with the free trade agreement reached between the EU and MERCOSUR. Macron said that the impact of the agreement on the agricultural market caused widespread concern, and France would not sacrifice its agricultural sovereignty. On the same day, Macron also said that Europe must strengthen its investment in security, build a European defense base and reduce its strategic dependence on the outside world. The EU and MERCOSUR reached a trade agreement on December 6th. The Southern Common Market was established in 1991. At present, its members are Brazil, Argentina, Uruguay, Paraguay and Bolivia, of which the first four are founding members. The vast majority of goods among member countries are free to trade without tariffs, and a unified foreign tariff policy is implemented. It is understood that the trade agreement needs to be approved by at least 15 of the 27 EU member States, and it needs to be voted by the European Parliament before it can be approved. France, Poland and Italy opposed the agreement. (CCTV News)Market News: The Director of the Federal Aviation Administration will step down on January 20th.Baiyang Pharmaceutical Group signed an agreement with Peking University Hospital. On December 12, Baiyang Pharmaceutical Group signed a cooperation agreement with Peking University No.1 Hospital, and obtained the exclusive right to patent, clinical development and registration, production and marketing of "targeted integrin small molecule inhibitor" in Peking University Hospital.

Royal Bank of Canada: The European Central Bank may move towards negative real interest rate. Royal Bank of Canada BlueBay Asset Management said that the European Central Bank may cut the interest rate below 2% next year, which the agency estimated to be a short-term neutral interest rate. Kaspar Hense, senior portfolio manager of the institution, said in a report that the core inflation rate is expected to be around 2.5% in the first half of 2025, which means that the real interest rate will be negative. He said that under the influence of unfavorable factors such as trade, continuous competitive pressure from other countries and financial problems, this should play a moderate supporting role in the economy.Germany's current account surplus in October was 12.497 billion euros.Market news: the agency said that the number of people applying for unemployment benefits in the United States jumped to the highest level in two months, but it was still at a low level.